参附注射液抗休克的物质基础及作用机制研究进展

参附注射液主要成分为人参皂苷和生物碱。主要用于阳气暴脱的厥脱症,相当于现代医学上的休克等症。参附注射液应用于临床休克等心血管疾病方面的治疗已近30年,疗效确切,且安全性好。故对其药效物质基础与药理作用机制的深入研究显得尤为重要。本文查阅了近10年来发表的相关文献,对参附注射液抗休克方面的物质基础及作用机制研究进行了综述,以期为参附注射液在心血管方面的临床应用提供一定参考。     

Monte Carlo模拟法进行双能X射线物质识别的研究

目的 提高X射线物质识别的准确性。方法 采用Monte Carlo方法对双能X射线物质识别进行模拟。结果 得到六种材料识别曲线与原子序数的关系。结论 Monte Carlo方法可以提高安检系统的材料分辨能力。     

Application of graphene-based nanomaterials in stem cells北大核心

BACKGROUND: As a kind of newly-developing nanomaterial, graphene has been used in many fields. Many recent studies have found that graphene-based nanomaterials can affect the biological behaviors of stem cells. OBJECTIVE: To review the application and progress of graphene-based nanomaterials in stem cells. METHODS: We searched the articles about the application of graphene-based nanomaterials in stem cells published in PubMed, Web of Science, and CNKI databases with the search terms “graphene, nanomaterials, stem cell” in English and Chinese. Finally, 57 articles met the criteria for review. RESULTS AND CONCLUSION: Graphene-based nanomaterials have good stability and corrosion resistance, high mechanical strength, good biocompatibility, which are accepted as one of the most promising nanomaterials in biomedicine. Stem cells are undifferentiated cells that can differentiate into various mature cells in human body, which have a broad application prospect in tissue engineering, regenerative medicine and other fields. Many recent studies have applied graphene-based nanomaterials to stem cell research and found that they can affect the growth, proliferation, adhesion and differentiation of stem cells, and these nanomaterials may affect the biological behavior of stem cells by regulating the expression of related genes and various signaling pathways. However, graphene-based nanomaterials have biological toxicity, which restrict their application in biological aspects. Moreover, most researches only involved cellular level, and it needs further animal studies and in vivo experimental researches. © 2022, Publishing House of Chinese Journal of Tissue Engineering Research. All rights reserved.     

Parameters influencing polymer particle layering of the dry coating process

The dry coating process is an emerging coating technology using neither organic solvents nor water. In contrast to liquid-borne coatings, coating material application and film formation are divided into two phases, the coating phase where the powdery coating material is applied together with the liquid plasticizer, and the curing phase. In this study the coating phase was characterized with respect to the forces acting between the polymer particles during material application. Atomic force microscopy was conducted measuring the interparticle forces which were related to the coating efficiency. The influence of different liquid additives on the interparticle forces and the coating efficiency were evaluated. HPMCAS was used as enteric resistant polymer, triethylcitrate (TEC), Myvacet (diacetylated monoglyceride) and a mixture of both as liquid additives. Interparticle forces were found to be similar when using TEC or a mixture of TEC and Myvacet. In contrast, interparticle forces were higher when using solely Myvacet. This is attributed to the fact that Myvacet does not penetrate into the polymer without TEC which is acting as a penetration enhancer. As Myvacet remains predominantly on the particle surface, capillary forces act between the particles explaining high interparticle forces. The highest interparticle force determined by AFM is in accordance to the highest coating efficiency which has been found for the corresponding coating formulation containing HPMCAS and Myvacet. Consequently, it is demonstrated that the ability of the liquid to remain on the surface of the polymer and to build up capillary forces is crucial for the material application.     

中医人体复杂巨系统理论科学建构

根据人体大脑信息控制系统理论的建立;五脏是人体巨系统的五个子系统;人体巨系统的＂能量信息＂系统和＂物质信息＂系统;阴阳五行在人体复杂巨系统的运用归纳分析,构建中医人体复杂巨系统理论。     

脉冲激光射线强化金属材料的几个问题

本文讨论了激光脉冲射线强化金属材料的几个问题:强化图形,材料性能,加工用量及表面涂层对被强化表面性能的影响。     

MIMF—1对B细胞功能的抑制效应

人精浆含有男性抑制物质(MIM)及其他抑制因子,它们可防止对精子及精浆产生免疫应答。本文报告,用Sephadex G-100过滤法从液化的正常人精液中制备MIM。犹如以往报道,从凝胶过滤中可分离出五个峰;而第一峰(称为MIMF-1)在SDS-PAGE上呈现一个区带。MIMF-1不仅能抑制SRBC进入小鼠体内所引起的免疫应答(以溶血空斑多少表示);亦能降低小鼠血清中SRBC抗体滴度(表1)。MIMF-1所致的免疫抑制作用或许与精液过敏或不育有关。     

Trimellitic anhydride exposure in a 55-gallon drum manufacturing plant: clinical, immunologic, and industrial hygiene evaluation

Nine workers at a 55-gallon drum manufacturing plant had history of exposure to a paint powder that contained trimellitic anhydride (TMA). Environmental monitoring revealed airborne levels of TMA to be over 100 times the OSHA permissible exposure limit of 0.04 mg/m3. The exposed workers were evaluated in a cross-sectional study by questionnaire, physical examination, screening pulmonary function tests, serial peak expiratory flow rates (PEFR), and serum antibody levels. Four workers had symptoms consistent with TMA-induced irritant effects. Three had symptoms and IgG levels consistent with TMA late respiratory systemic syndrome (LRSS). Two of these three had PEFR changes that showed significant drops (greater than 20%) 12-18 hours after the end of a work shift. The material safety data sheet for the paint powder failed to list TMA as an ingredient. Despite the well-described toxic effects of TMA, the present study documents that TMA-related illness may continue to be a problem in situations where workers and management are not properly notified of the potential hazards. The measurement of PEFR may be useful in identifying TMA-exposed workers with LRSS.     

中药汤剂药效物质基础研究的计算机辅助系统设计

目的 按照中药汤剂药效物质基础研究方法编写实验流程设计与试验结果分析的软件系统.方法 在.net平台上,使用Visual Basic 2005,结合数据库编程技术开发可同时分析WATERS和AGILENT的液相色谱数据且不依赖原HPLC系统的数据处理和积分软件的中药汤剂药效物质基础研究辅助软件.结果 编写出<中药汤剂药效物质基础研究辅助执行及数据分析系统>的软件.结论 通过软件辅助,可使中药汤剂药效物质基础研究方法的执行更加清晰,数据的分析简便快捷.